The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for KAT6B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KAT6B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KAT6B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:74,784,206–74,784,769 | 41.1 kb | Distal (>10kb) Multiome | 13 | |
| chr10:74,813,288–74,813,763 | 11.9 kb | Distal (>10kb) Multiome | 140 | |
| chr10:74,824,308–74,827,412 | 923 bp | At TSS Multiome | 1014 | |
| chr10:74,921,339–74,922,280 | 96.4 kb | Distal (>10kb) Multiome | 350 | |
| chr10:75,043,531–75,044,056 | 218.3 kb | Distal (>10kb) Multiome | 156 | |
| chr10:75,058,930–75,059,944 | 234.0 kb | Distal (>10kb) Multiome | 137 | |
| chr10:75,079,403–75,080,508 | 254.4 kb | Distal (>10kb) Multiome | 189 | |
| chr10:75,099,885–75,100,763 | 274.7 kb | Distal (>10kb) Multiome HiCAR | 419 | |
| chr10:75,111,043–75,112,358 | 286.0 kb | Distal (>10kb) Multiome | 857 |
Genomic view of the KAT6B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.