KARS1

lysyl-tRNA synthetase 1 | KARS2, DFNB89, KARS

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Member of: DE-1

Biological processes 59 terms

ATP binding (GO:0005524)ATP:ADP adenylyltransferase activity (GO:0003877)ATP:ADP adenylyltransferase activity (GO:0003877)ERK1 and ERK2 cascade (GO:0070371)ERK1 and ERK2 cascade (GO:0070371)amino acid binding (GO:0016597)aminoacyl-tRNA ligase activity (GO:0004812)aminoacyl-tRNA synthetase multienzyme complex (GO:0017101)aminoacyl-tRNA synthetase multienzyme complex (GO:0017101)aminoacyl-tRNA synthetase multienzyme complex (GO:0017101)basophil activation involved in immune response (GO:0002276)basophil activation involved in immune response (GO:0002276)basophil activation involved in immune response (GO:0002276)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)diadenosine tetraphosphate biosynthetic process (GO:0015966)diadenosine tetraphosphate biosynthetic process (GO:0015966)diadenosine tetraphosphate biosynthetic process (GO:0015966)diadenosine tetraphosphate biosynthetic process (GO:0015966)extracellular region (GO:0005576)extracellular region (GO:0005576)identical protein binding (GO:0042802)lysine-tRNA ligase activity (GO:0004824)lysine-tRNA ligase activity (GO:0004824)lysine-tRNA ligase activity (GO:0004824)lysyl-tRNA aminoacylation (GO:0006430)lysyl-tRNA aminoacylation (GO:0006430)lysyl-tRNA aminoacylation (GO:0006430)mitochondrial matrix (GO:0005759)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)nucleic acid binding (GO:0003676)nucleoplasm (GO:0005654)nucleotide binding (GO:0000166)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of inflammatory response to antigenic stimulus (GO:0002863)positive regulation of macrophage activation (GO:0043032)positive regulation of macrophage activation (GO:0043032)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)response to X-ray (GO:0010165)scaffold protein binding (GO:0097110)tRNA aminoacylation for protein translation (GO:0006418)tRNA aminoacylation for protein translation (GO:0006418)tRNA binding (GO:0000049)tRNA binding (GO:0000049)tRNA binding (GO:0000049)tRNA processing (GO:0008033)

Expression (TPM)

TFs regulating KARS1 0 TFs

Transcription factors with Perturb-seq knockdown data for KARS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KARS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to KARS1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KARS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:75,432,825–75,434,426	215.1 kb	Distal (>10kb) Multiome	1143
chr16:75,463,598–75,465,197	183.9 kb	Distal (>10kb) Multiome	999
chr16:75,494,705–75,495,929	153.2 kb	Distal (>10kb) Multiome	341
chr16:75,516,521–75,518,019	131.2 kb	Distal (>10kb) Multiome	921
chr16:75,555,188–75,556,662	93.4 kb	Distal (>10kb) Multiome	900
chr16:75,565,779–75,567,123	82.3 kb	Distal (>10kb) Multiome	834
chr16:75,593,861–75,594,383	54.5 kb	Distal (>10kb) Multiome	336
chr16:75,622,804–75,623,690	25.4 kb	Distal (>10kb) Multiome	852
chr16:75,647,337–75,649,003	244 bp	At TSS Multiome	1002
chr16:75,649,708–75,650,004	2.1 kb	Proximal (<10kb)	103
chr16:77,190,160–77,191,630	1542.2 kb	Distal (>10kb) Multiome HiCAR	915
chr16:77,211,464–77,213,653	1563.7 kb	Distal (>10kb) Multiome HiCAR	644

Genome Browser

Genomic view of the KARS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.