Predicted to enable histone acetyltransferase binding activity. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of NSL complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for KANSL1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KANSL1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KANSL1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:209,960,058–209,961,333 | 210.4 kb | Distal (>10kb) Multiome | 269 | |
| chr2:209,985,387–209,986,656 | 185.5 kb | Distal (>10kb) Multiome HiCAR | 197 | |
| chr2:210,002,022–210,003,279 | 168.7 kb | Distal (>10kb) Multiome | 811 | |
| chr2:210,169,996–210,172,503 | 41 bp | At TSS Multiome | 1015 | |
| chr2:210,177,699–210,178,146 | 7.0 kb | Proximal (<10kb) | 118 | |
| chr2:210,179,774–210,180,679 | 9.1 kb | Proximal (<10kb) | 40 | |
| chr2:210,181,086–210,182,197 | 10.4 kb | Distal (>10kb) Multiome | 168 | |
| chr2:210,224,566–210,225,799 | 53.8 kb | Distal (>10kb) Multiome | 493 |
Genomic view of the KANSL1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.