This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for KANK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KANK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KANK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:10,928,331–10,929,395 | 267.0 kb | Distal (>10kb) Multiome | 860 | |
| chr19:10,960,232–10,961,863 | 234.8 kb | Distal (>10kb) Multiome | 1016 | |
| chr19:11,089,041–11,091,015 | 106.4 kb | Distal (>10kb) Multiome | 964 | |
| chr19:11,137,551–11,138,233 | 57.8 kb | Distal (>10kb) Multiome | 584 | |
| chr19:11,155,520–11,156,298 | 39.8 kb | Distal (>10kb) Multiome | 754 | |
| chr19:11,196,759–11,198,184 | 2.0 kb | Proximal (<10kb) Multiome | 728 | |
| chr19:11,203,927–11,204,096 | 8.2 kb | Proximal (<10kb) | 276 | |
| chr19:11,243,345–11,243,968 | 47.8 kb | Distal (>10kb) Multiome | 448 | |
| chr19:11,262,060–11,262,653 | 66.8 kb | Distal (>10kb) Multiome | 406 | |
| chr19:11,339,100–11,339,837 | 144.0 kb | Distal (>10kb) Multiome | 506 | |
| chr19:11,346,053–11,346,958 | 150.8 kb | Distal (>10kb) Multiome | 676 | |
| chr19:11,355,078–11,355,735 | 159.7 kb | Distal (>10kb) Multiome | 382 | |
| chr19:11,361,368–11,362,625 | 166.0 kb | Distal (>10kb) Multiome | 256 | |
| chr19:11,374,474–11,375,717 | 179.3 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,380,761–11,382,262 | 185.7 kb | Distal (>10kb) Multiome | 798 | |
| chr19:11,382,830–11,384,509 | 188.7 kb | Distal (>10kb) Multiome | 761 | |
| chr19:11,418,061–11,419,498 | 222.9 kb | Distal (>10kb) Multiome | 421 | |
| chr19:11,420,614–11,422,979 | 226.5 kb | Distal (>10kb) Multiome | 507 | |
| chr19:11,434,817–11,436,365 | 239.7 kb | Distal (>10kb) Multiome | 927 | |
| chr19:11,479,217–11,480,146 | 283.9 kb | Distal (>10kb) Multiome | 394 | |
| chr19:11,481,847–11,483,040 | 287.0 kb | Distal (>10kb) Multiome | 938 |
Genomic view of the KANK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.