The function of this gene has not yet been defined, however, the encoded protein shares similarity with the human (41% identical) and mouse (34% identical) jerky gene products. This protein may act as a nuclear regulatory protein. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for JRKL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JRKL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JRKL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:95,144,387–95,145,222 | 1245.1 kb | Distal (>10kb) Multiome HiCAR | 127 | |
| chr11:95,149,652–95,152,295 | 1240.1 kb | Distal (>10kb) Multiome HiCAR | 685 | |
| chr11:95,788,868–95,791,310 | 600.2 kb | Distal (>10kb) Multiome HiCAR | 1058 | |
| chr11:95,923,511–95,924,679 | 465.9 kb | Distal (>10kb) Multiome HiCAR | 950 | |
| chr11:96,167,040–96,167,627 | 222.6 kb | Distal (>10kb) Multiome | 97 | |
| chr11:96,180,222–96,181,389 | 209.0 kb | Distal (>10kb) Multiome | 133 | |
| chr11:96,211,587–96,212,750 | 177.6 kb | Distal (>10kb) Multiome | 391 | |
| chr11:96,243,217–96,244,039 | 146.6 kb | Distal (>10kb) Multiome | 569 | |
| chr11:96,342,718–96,343,737 | 46.7 kb | Distal (>10kb) Multiome | 568 | |
| chr11:96,389,261–96,390,676 | 120 bp | At TSS Multiome | 898 | |
| chr11:96,586,158–96,587,250 | 196.6 kb | Distal (>10kb) Multiome | 210 |
Genomic view of the JRKL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.