Involved in endocytosis involved in viral entry into host cell and regulation of calcium-mediated signaling. Located in cytosol; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for JPT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JPT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JPT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:1,378,844–1,380,439 | 298.5 kb | Distal (>10kb) Multiome | 782 | |
| chr16:1,408,010–1,408,819 | 269.9 kb | Distal (>10kb) Multiome | 546 | |
| chr16:1,413,643–1,415,278 | 263.5 kb | Distal (>10kb) Multiome | 661 | |
| chr16:1,420,269–1,421,402 | 257.4 kb | Distal (>10kb) Multiome | 897 | |
| chr16:1,474,566–1,475,411 | 203.2 kb | Distal (>10kb) Multiome | 915 | |
| chr16:1,492,797–1,493,962 | 185.0 kb | Distal (>10kb) Multiome | 710 | |
| chr16:1,610,035–1,611,264 | 67.6 kb | Distal (>10kb) Multiome | 745 | |
| chr16:1,611,870–1,612,834 | 66.0 kb | Distal (>10kb) Multiome | 718 | |
| chr16:1,677,899–1,679,024 | 84 bp | At TSS Multiome | 709 | |
| chr16:1,705,380–1,706,702 | 27.8 kb | Distal (>10kb) Multiome | 933 | |
| chr16:1,763,511–1,764,353 | 85.7 kb | Distal (>10kb) Multiome | 261 | |
| chr16:1,770,847–1,771,973 | 93.3 kb | Distal (>10kb) Multiome | 485 | |
| chr16:1,772,565–1,774,049 | 95.1 kb | Distal (>10kb) Multiome | 956 | |
| chr16:1,781,749–1,783,420 | 104.5 kb | Distal (>10kb) Multiome | 761 | |
| chr16:1,826,102–1,827,535 | 148.6 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:1,918,171–1,918,773 | 240.2 kb | Distal (>10kb) Multiome | 129 | |
| chr16:1,929,283–1,930,271 | 251.5 kb | Distal (>10kb) Multiome | 780 | |
| chr16:1,942,671–1,943,761 | 265.1 kb | Distal (>10kb) Multiome | 750 | |
| chr16:1,958,923–1,960,140 | 281.2 kb | Distal (>10kb) Multiome | 826 | |
| chr16:1,964,300–1,965,434 | 286.6 kb | Distal (>10kb) Multiome | 933 | |
| chr16:1,971,481–1,972,435 | 293.7 kb | Distal (>10kb) Multiome | 1010 |
Genomic view of the JPT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.