JPH2

junctophilin 2 | JP-2, JP2

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008]

Biological processes 37 terms

DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)Z disc (GO:0030018)calcium ion homeostasis (GO:0055074)calcium ion transport into cytosol (GO:0060402)calcium ion transport into cytosol (GO:0060402)core promoter sequence-specific DNA binding (GO:0001046)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)junctional membrane complex (GO:0030314)junctional membrane complex (GO:0030314)junctional sarcoplasmic reticulum membrane (GO:0014701)junctional sarcoplasmic reticulum membrane (GO:0014701)membrane (GO:0016020)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)nucleus (GO:0005634)phosphatidic acid binding (GO:0070300)phosphatidylinositol-3,4,5-trisphosphate binding (GO:0005547)phosphatidylinositol-3,5-bisphosphate binding (GO:0080025)phosphatidylinositol-3-phosphate binding (GO:0032266)phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)phosphatidylinositol-4-phosphate binding (GO:0070273)phosphatidylinositol-5-phosphate binding (GO:0010314)phosphatidylserine binding (GO:0001786)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)regulation of cardiac muscle tissue development (GO:0055024)regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)sarcoplasmic reticulum (GO:0016529)sarcoplasmic reticulum (GO:0016529)sarcoplasmic reticulum membrane (GO:0033017)

Expression (TPM)