This gene encodes a protein containing a Josephin domain. Josephin domain-containing proteins are deubiquitinating enzymes which catalyze the hydrolysis of the bond between the C-terminal glycine of the ubiquitin peptide and protein substrates. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for JOSD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JOSD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JOSD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:50,311,942–50,312,908 | 198.9 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,313,900–50,314,529 | 196.9 kb | Distal (>10kb) Multiome | 114 | |
| chr19:50,315,313–50,316,408 | 195.2 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,325,322–50,326,594 | 185.4 kb | Distal (>10kb) Multiome | 748 | |
| chr19:50,328,019–50,330,066 | 181.9 kb | Distal (>10kb) Multiome | 699 | |
| chr19:50,330,341–50,331,411 | 180.3 kb | Distal (>10kb) Multiome | 479 | |
| chr19:50,332,395–50,334,325 | 177.6 kb | Distal (>10kb) Multiome | 907 | |
| chr19:50,368,630–50,369,092 | 142.3 kb | Distal (>10kb) Multiome | 311 | |
| chr19:50,376,225–50,377,452 | 134.5 kb | Distal (>10kb) Multiome | 931 | |
| chr19:50,383,444–50,384,805 | 127.0 kb | Distal (>10kb) Multiome | 863 | |
| chr19:50,414,638–50,415,204 | 96.3 kb | Distal (>10kb) Multiome | 377 | |
| chr19:50,431,430–50,432,503 | 79.4 kb | Distal (>10kb) Multiome | 530 | |
| chr19:50,475,914–50,477,044 | 34.6 kb | Distal (>10kb) Multiome | 622 | |
| chr19:50,510,707–50,511,948 | 166 bp | At TSS Multiome | 794 | |
| chr19:50,556,266–50,557,084 | 45.5 kb | Distal (>10kb) Multiome | 463 | |
| chr19:50,639,246–50,640,210 | 128.5 kb | Distal (>10kb) Multiome | 326 | |
| chr19:50,657,814–50,659,557 | 147.1 kb | Distal (>10kb) Multiome | 790 | |
| chr19:50,723,765–50,725,772 | 213.7 kb | Distal (>10kb) Multiome | 721 | |
| chr19:50,728,202–50,728,738 | 217.4 kb | Distal (>10kb) Multiome | 345 | |
| chr19:50,804,189–50,805,375 | 293.7 kb | Distal (>10kb) Multiome | 919 |
Genomic view of the JOSD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.