Enables peptidyl-lysine 4-dioxygenase activity. Involved in positive regulation of translational termination and protein hydroxylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for JMJD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JMJD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JMJD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:227,541,755–227,542,988 | 192.7 kb | Distal (>10kb) Multiome | 600 | |
| chr1:227,563,282–227,564,196 | 171.6 kb | Distal (>10kb) Multiome | 889 | |
| chr1:227,728,086–227,729,232 | 6.8 kb | Proximal (<10kb) Multiome | 590 | |
| chr1:227,729,684–227,729,882 | 5.4 kb | Proximal (<10kb) | 152 | |
| chr1:227,730,363–227,730,812 | 4.7 kb | Proximal (<10kb) Multiome | 276 | |
| chr1:227,734,745–227,735,925 | 78 bp | At TSS Multiome | 1052 | |
| chr1:227,787,209–227,789,037 | 52.9 kb | Distal (>10kb) Multiome | 579 | |
| chr1:227,946,348–227,948,809 | 211.4 kb | Distal (>10kb) Multiome HiCAR | 645 | |
| chr1:228,004,351–228,004,883 | 269.3 kb | Distal (>10kb) Multiome | 154 |
Genomic view of the JMJD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.