The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for JAG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JAG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JAG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:104,932,604–104,933,678 | 235.5 kb | Distal (>10kb) Multiome | 498 | |
| chr14:104,967,607–104,968,024 | 200.9 kb | Distal (>10kb) Multiome | 196 | |
| chr14:104,977,531–104,979,147 | 190.4 kb | Distal (>10kb) Multiome | 387 | |
| chr14:104,985,398–104,986,377 | 183.1 kb | Distal (>10kb) Multiome | 518 | |
| chr14:105,020,271–105,022,072 | 147.6 kb | Distal (>10kb) Multiome | 813 | |
| chr14:105,045,704–105,046,235 | 122.9 kb | Distal (>10kb) Multiome | 635 | |
| chr14:105,086,627–105,087,884 | 81.8 kb | Distal (>10kb) Multiome | 590 | |
| chr14:105,092,908–105,094,307 | 74.9 kb | Distal (>10kb) Multiome | 495 | |
| chr14:105,167,331–105,169,463 | 208 bp | At TSS Multiome | 496 | |
| chr14:105,180,714–105,181,828 | 12.4 kb | Distal (>10kb) Multiome | 392 | |
| chr14:105,248,175–105,249,386 | 79.7 kb | Distal (>10kb) Multiome | 403 | |
| chr14:105,299,994–105,301,984 | 132.5 kb | Distal (>10kb) Multiome | 829 | |
| chr14:105,313,768–105,315,755 | 145.8 kb | Distal (>10kb) Multiome | 584 | |
| chr14:105,398,137–105,398,986 | 229.7 kb | Distal (>10kb) Multiome | 870 | |
| chr14:105,411,005–105,411,818 | 242.6 kb | Distal (>10kb) Multiome | 384 | |
| chr14:105,414,940–105,415,397 | 246.3 kb | Distal (>10kb) Multiome | 447 | |
| chr14:105,419,281–105,420,109 | 251.1 kb | Distal (>10kb) Multiome | 570 | |
| chr14:105,448,471–105,448,924 | 279.9 kb | Distal (>10kb) Multiome | 304 |
Genomic view of the JAG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.