Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IZUMO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IZUMO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IZUMO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:49,866,817–49,868,124 | 295.9 kb | Distal (>10kb) Multiome | 874 | |
| chr19:49,869,068–49,870,398 | 293.7 kb | Distal (>10kb) Multiome | 832 | |
| chr19:49,875,842–49,878,576 | 285.5 kb | Distal (>10kb) Multiome | 1153 | |
| chr19:49,889,853–49,891,381 | 272.6 kb | Distal (>10kb) Multiome | 640 | |
| chr19:49,928,884–49,930,473 | 233.2 kb | Distal (>10kb) Multiome | 1141 | |
| chr19:49,987,157–49,987,669 | 175.9 kb | Distal (>10kb) Multiome | 1095 | |
| chr19:50,024,875–50,026,285 | 137.7 kb | Distal (>10kb) Multiome | 1137 | |
| chr19:50,147,523–50,148,432 | 15.1 kb | Distal (>10kb) Multiome | 615 | |
| chr19:50,203,034–50,204,072 | 40.2 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,205,195–50,205,903 | 42.1 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,311,942–50,312,908 | 149.0 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,313,900–50,314,529 | 150.9 kb | Distal (>10kb) Multiome | 114 | |
| chr19:50,315,313–50,316,408 | 152.7 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,325,322–50,326,594 | 162.5 kb | Distal (>10kb) Multiome | 748 | |
| chr19:50,328,019–50,330,066 | 166.1 kb | Distal (>10kb) Multiome | 699 | |
| chr19:50,330,341–50,331,411 | 167.6 kb | Distal (>10kb) Multiome | 479 | |
| chr19:50,332,395–50,334,325 | 170.2 kb | Distal (>10kb) Multiome | 907 | |
| chr19:50,368,630–50,369,092 | 205.7 kb | Distal (>10kb) Multiome | 311 | |
| chr19:50,376,225–50,377,452 | 213.6 kb | Distal (>10kb) Multiome | 931 | |
| chr19:50,383,444–50,384,805 | 220.9 kb | Distal (>10kb) Multiome | 863 | |
| chr19:50,414,638–50,415,204 | 251.7 kb | Distal (>10kb) Multiome | 377 | |
| chr19:50,431,430–50,432,503 | 268.6 kb | Distal (>10kb) Multiome | 530 |
Genomic view of the IZUMO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.