The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for IZUMO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IZUMO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IZUMO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:48,737,434–48,737,704 | 9.2 kb | Proximal (<10kb) | 172 | |
| chr19:48,738,441–48,739,812 | 7.1 kb | Proximal (<10kb) | 743 | |
| chr19:48,741,194–48,741,939 | 5.0 kb | Proximal (<10kb) | 350 | |
| chr19:48,745,316–48,745,509 | 1.4 kb | Proximal (<10kb) | 231 | |
| chr19:48,746,830–48,747,395 | at TSS | At TSS | 402 | |
| chr19:48,752,314–48,753,547 | 5.4 kb | Proximal (<10kb) | 545 |
Genomic view of the IZUMO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.