Transcription factors with Perturb-seq knockdown data for ITPRIP-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITPRIP-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITPRIP-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:104,317,272–104,317,761 | 5.6 kb | Proximal (<10kb) | 113 | |
| chr10:104,323,140–104,323,496 | at TSS | At TSS | 23 | |
| chr10:104,328,024–104,329,489 | 4.7 kb | Proximal (<10kb) | 537 | |
| chr10:104,331,220–104,332,050 | 7.9 kb | Proximal (<10kb) | 374 | |
| chr10:104,332,513–104,332,700 | 9.1 kb | Proximal (<10kb) | 123 | |
| chr10:104,333,107–104,333,747 | 9.7 kb | Proximal (<10kb) | 119 |
Genomic view of the ITPRIP-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.