This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for ITIH5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITIH5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITIH5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:7,407,757–7,409,381 | 258.4 kb | Distal (>10kb) Multiome | 452 | |
| chr10:7,410,337–7,413,433 | 256.0 kb | Distal (>10kb) Multiome | 551 | |
| chr10:7,466,885–7,467,532 | 199.7 kb | Distal (>10kb) Multiome | 76 | |
| chr10:7,513,605–7,514,402 | 152.9 kb | Distal (>10kb) Multiome HiCAR | 112 | |
| chr10:7,540,399–7,542,174 | 126.1 kb | Distal (>10kb) Multiome HiCAR | 420 | |
| chr10:7,551,477–7,552,685 | 114.9 kb | Distal (>10kb) Multiome | 160 | |
| chr10:7,605,258–7,606,229 | 61.2 kb | Distal (>10kb) Multiome | 80 | |
| chr10:7,618,865–7,620,103 | 47.4 kb | Distal (>10kb) Multiome | 246 | |
| chr10:7,623,024–7,623,321 | 3.4 kb | Proximal (<10kb) | 89 | |
| chr10:7,666,540–7,667,065 | at TSS | At TSS | 197 | |
| chr10:7,667,487–7,668,354 | 734 bp | At TSS Multiome | 159 | |
| chr10:7,787,377–7,789,109 | 121.1 kb | Distal (>10kb) Multiome | 843 | |
| chr10:7,818,056–7,819,396 | 151.5 kb | Distal (>10kb) Multiome | 897 |
Genomic view of the ITIH5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.