This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for ITGA2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITGA2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITGA2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:44,095,480–44,096,263 | 289.4 kb | Distal (>10kb) Multiome | 713 | |
| chr17:44,110,949–44,111,605 | 274.1 kb | Distal (>10kb) Multiome | 856 | |
| chr17:44,122,999–44,124,340 | 261.6 kb | Distal (>10kb) Multiome | 883 | |
| chr17:44,141,505–44,142,741 | 243.5 kb | Distal (>10kb) Multiome | 857 | |
| chr17:44,168,259–44,168,849 | 216.8 kb | Distal (>10kb) Multiome | 475 | |
| chr17:44,186,111–44,187,514 | 198.5 kb | Distal (>10kb) Multiome | 917 | |
| chr17:44,198,550–44,201,037 | 185.2 kb | Distal (>10kb) Multiome | 868 | |
| chr17:44,210,257–44,210,930 | 174.8 kb | Distal (>10kb) Multiome | 568 | |
| chr17:44,218,107–44,221,629 | 166.7 kb | Distal (>10kb) Multiome | 936 | |
| chr17:44,221,765–44,222,816 | 163.1 kb | Distal (>10kb) Multiome | 597 | |
| chr17:44,307,755–44,309,164 | 76.9 kb | Distal (>10kb) Multiome | 726 | |
| chr17:44,314,945–44,315,776 | 70.1 kb | Distal (>10kb) Multiome | 273 | |
| chr17:44,316,273–44,316,728 | 68.9 kb | Distal (>10kb) Multiome | 183 | |
| chr17:44,324,218–44,325,841 | 60.5 kb | Distal (>10kb) Multiome | 852 | |
| chr17:44,326,610–44,327,149 | 58.4 kb | Distal (>10kb) Multiome | 599 | |
| chr17:44,344,826–44,346,001 | 40.2 kb | Distal (>10kb) Multiome | 837 | |
| chr17:44,353,667–44,355,182 | 30.6 kb | Distal (>10kb) Multiome | 393 | |
| chr17:44,363,447–44,364,077 | 21.5 kb | Distal (>10kb) Multiome | 502 | |
| chr17:44,374,688–44,375,216 | 10.5 kb | Distal (>10kb) Multiome | 299 | |
| chr17:44,384,542–44,386,175 | 113 bp | At TSS Multiome | 553 | |
| chr17:44,502,912–44,504,091 | 118.2 kb | Distal (>10kb) Multiome | 999 | |
| chr17:44,539,724–44,540,529 | 154.8 kb | Distal (>10kb) Multiome | 135 | |
| chr17:44,543,007–44,544,301 | 157.9 kb | Distal (>10kb) Multiome | 384 | |
| chr17:44,556,129–44,558,277 | 171.9 kb | Distal (>10kb) Multiome | 696 | |
| chr17:44,608,340–44,608,975 | 223.2 kb | Distal (>10kb) Multiome | 208 | |
| chr17:44,628,394–44,629,188 | 243.3 kb | Distal (>10kb) Multiome | 285 | |
| chr17:44,656,036–44,656,706 | 271.0 kb | Distal (>10kb) Multiome | 280 |
Genomic view of the ITGA2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.