IRAK1

IRAK1

interleukin 1 receptor associated kinase 1 | IRAK, pelle

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Biological processes 85 terms

ATP binding (GO:0005524)JNK cascade (GO:0007254)MyD88-dependent toll-like receptor signaling pathway (GO:0002755)MyD88-dependent toll-like receptor signaling pathway (GO:0002755)NLRP3 inflammasome complex assembly (GO:0044546)Toll signaling pathway (GO:0008063)canonical NF-kappaB signal transduction (GO:0007249)canonical NF-kappaB signal transduction (GO:0007249)canonical NF-kappaB signal transduction (GO:0007249)cell surface (GO:0009986)cellular response to heat (GO:0034605)cellular response to hypoxia (GO:0071456)cellular response to lipopolysaccharide (GO:0071222)cytokine-mediated signaling pathway (GO:0019221)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)endosome membrane (GO:0010008)heat shock protein binding (GO:0031072)identical protein binding (GO:0042802)innate immune response (GO:0045087)innate immune response (GO:0045087)interleukin-1-mediated signaling pathway (GO:0070498)interleukin-1-mediated signaling pathway (GO:0070498)interleukin-1-mediated signaling pathway (GO:0070498)interleukin-1-mediated signaling pathway (GO:0070498)interleukin-1-mediated signaling pathway (GO:0070498)interleukin-1-mediated signaling pathway (GO:0070498)interleukin-33-mediated signaling pathway (GO:0038172)intracellular signal transduction (GO:0035556)kinase activity (GO:0016301)lipid droplet (GO:0005811)lipid droplet (GO:0005811)lipopolysaccharide-mediated signaling pathway (GO:0031663)lipopolysaccharide-mediated signaling pathway (GO:0031663)lipopolysaccharide-mediated signaling pathway (GO:0031663)membrane (GO:0016020)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of intracellular signal transduction (GO:1902533)positive regulation of leukocyte adhesion to vascular endothelial cell (GO:1904996)positive regulation of smooth muscle cell proliferation (GO:0048661)positive regulation of type I interferon production (GO:0032481)protein autophosphorylation (GO:0046777)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein kinase binding (GO:0019901)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)regulation of MAP kinase activity (GO:0043405)regulation of cytokine-mediated signaling pathway (GO:0001959)regulation of gene expression (GO:0010468)response to interleukin-1 (GO:0070555)response to lipopolysaccharide (GO:0032496)signal transduction (GO:0007165)signaling adaptor activity (GO:0035591)toll-like receptor 2 signaling pathway (GO:0034134)toll-like receptor 2 signaling pathway (GO:0034134)toll-like receptor 2 signaling pathway (GO:0034134)toll-like receptor 4 signaling pathway (GO:0034142)toll-like receptor 9 signaling pathway (GO:0034162)toll-like receptor 9 signaling pathway (GO:0034162)toll-like receptor signaling pathway (GO:0002224)toll-like receptor signaling pathway (GO:0002224)type I interferon-mediated signaling pathway (GO:0060337)

Expression (TPM)

TFs regulating IRAK1 0 TFs

Transcription factors with Perturb-seq knockdown data for IRAK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IRAK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to IRAK1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IRAK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chrX:153,723,829–153,725,285	295.3 kb	Distal (>10kb) Multiome	620
	chrX:153,726,395–153,727,168	293.0 kb	Distal (>10kb) Multiome	529
	chrX:153,793,808–153,795,045	225.5 kb	Distal (>10kb) Multiome	733
	chrX:153,875,415–153,875,856	144.2 kb	Distal (>10kb) Multiome	847
	chrX:153,878,887–153,879,684	140.7 kb	Distal (>10kb) Multiome	235
	chrX:153,927,955–153,928,728	91.5 kb	Distal (>10kb) Multiome	711
	chrX:153,934,763–153,935,658	84.7 kb	Distal (>10kb) Multiome	446
	chrX:153,970,913–153,973,065	47.4 kb	Distal (>10kb) Multiome	857
	chrX:154,019,828–154,020,283	at TSS	At TSS	364
	chrX:154,097,040–154,098,161	77.9 kb	Distal (>10kb) Multiome	537
	chrX:154,136,648–154,137,146	117.0 kb	Distal (>10kb) Multiome	391

Genome Browser

Genomic view of the IRAK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.