Involved in flagellated sperm motility and mating. Predicted to be located in sperm flagellum. Predicted to be part of radial spoke. Predicted to be active in acrosomal vesicle and motile cilium. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IQUB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IQUB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IQUB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:122,143,073–122,145,002 | 1390.3 kb | Distal (>10kb) Multiome HiCAR | 722 | |
| chr7:123,284,880–123,285,858 | 249.2 kb | Distal (>10kb) Multiome | 233 | |
| chr7:123,527,328–123,528,618 | 6.0 kb | Proximal (<10kb) | 316 | |
| chr7:123,532,869–123,533,213 | 1.4 kb | Proximal (<10kb) | 145 | |
| chr7:123,533,937–123,535,843 | 251 bp | At TSS Multiome | 560 | |
| chr7:123,557,224–123,558,428 | 23.3 kb | Distal (>10kb) Multiome | 732 | |
| chr7:123,594,565–123,595,316 | 60.3 kb | Distal (>10kb) Multiome | 183 | |
| chr7:123,637,247–123,638,386 | 103.4 kb | Distal (>10kb) Multiome | 95 | |
| chr7:123,657,889–123,659,811 | 123.8 kb | Distal (>10kb) Multiome | 165 | |
| chr7:123,692,360–123,692,863 | 158.1 kb | Distal (>10kb) Multiome | 179 | |
| chr7:123,747,604–123,749,779 | 214.5 kb | Distal (>10kb) Multiome | 1065 |
Genomic view of the IQUB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.