INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for INTS12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INTS12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INTS12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:105,472,920–105,474,489 | 234.7 kb | Distal (>10kb) Multiome HiCAR | 991 | |
| chr4:105,555,050–105,556,083 | 153.1 kb | Distal (>10kb) Multiome | 189 | |
| chr4:105,605,064–105,606,238 | 103.1 kb | Distal (>10kb) Multiome | 262 | |
| chr4:105,704,625–105,705,315 | 2.8 kb | Proximal (<10kb) | 7 | |
| chr4:105,708,104–105,709,494 | 89 bp | At TSS Multiome | 1158 | |
| chr4:105,894,711–105,896,958 | 186.5 kb | Distal (>10kb) Multiome | 578 |
Genomic view of the INTS12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.