INPP5K
inositol polyphosphate-5-phosphatase K | SKIP

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Biological processes 92 terms
G protein-coupled receptor signaling pathway (GO:0007186)G protein-coupled receptor signaling pathway (GO:0007186)actin cytoskeleton organization (GO:0030036)cellular response to cAMP (GO:0071320)cellular response to cAMP (GO:0071320)cellular response to epidermal growth factor stimulus (GO:0071364)cellular response to hormone stimulus (GO:0032870)cellular response to hormone stimulus (GO:0032870)cellular response to insulin stimulus (GO:0032869)cellular response to oxygen-containing compound (GO:1901701)cellular response to tumor necrosis factor (GO:0071356)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)glucose homeostasis (GO:0042593)glycerolipid metabolic process (GO:0046486)host-mediated suppression of viral transcription (GO:0043922)inositol bisphosphate phosphatase activity (GO:0016312)inositol bisphosphate phosphatase activity (GO:0016312)inositol bisphosphate phosphatase activity (GO:0016312)inositol trisphosphate phosphatase activity (GO:0046030)inositol trisphosphate phosphatase activity (GO:0046030)inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity (GO:0052659)inositol-1,4,5-trisphosphate 5-phosphatase activity (GO:0052658)inositol-polyphosphate 5-phosphatase activity (GO:0004445)lipid phosphatase activity (GO:0042577)membrane (GO:0016020)membrane (GO:0016020)negative regulation of D-glucose transmembrane transport (GO:0010829)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of RNA biosynthetic process (GO:1902679)negative regulation of calcium ion transport (GO:0051926)negative regulation of dephosphorylation (GO:0035305)negative regulation of dephosphorylation (GO:0035305)negative regulation of glycogen biosynthetic process (GO:0045719)negative regulation of glycogen biosynthetic process (GO:0045719)negative regulation of glycogen biosynthetic process (GO:0045719)negative regulation of insulin receptor signaling pathway (GO:0046627)negative regulation of insulin receptor signaling pathway (GO:0046627)negative regulation of insulin receptor signaling pathway (GO:0046627)negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051898)negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051898)negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051898)negative regulation of protein targeting to membrane (GO:0090315)negative regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045869)negative regulation of stress fiber assembly (GO:0051497)neuron projection (GO:0043005)neuron projection (GO:0043005)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)phosphatase activity (GO:0016791)phosphatidylinositol biosynthetic process (GO:0006661)phosphatidylinositol dephosphorylation (GO:0046856)phosphatidylinositol dephosphorylation (GO:0046856)phosphatidylinositol dephosphorylation (GO:0046856)phosphatidylinositol phosphate 5-phosphatase activity (GO:0034595)phosphatidylinositol trisphosphate phosphatase activity (GO:0034594)phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity (GO:0034485)phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity (GO:0034485)phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity (GO:0034485)phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity (GO:0034485)phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (GO:0004439)phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (GO:0004439)phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (GO:0004439)phospholipid metabolic process (GO:0006644)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of renal water transport (GO:2001153)positive regulation of renal water transport (GO:2001153)positive regulation of urine volume (GO:0035810)positive regulation of urine volume (GO:0035810)protein binding (GO:0005515)protein localization to plasma membrane (GO:0072659)protein localization to plasma membrane (GO:0072659)regulation of glycogen biosynthetic process (GO:0005979)regulation of glycogen biosynthetic process (GO:0005979)regulation of transport (GO:0051049)response to insulin (GO:0032868)ruffle (GO:0001726)ruffle (GO:0001726)ruffle assembly (GO:0097178)ruffle membrane (GO:0032587)trans-Golgi network (GO:0005802)vasopressin receptor activity (GO:0005000)vasopressin receptor activity (GO:0005000)
Expression (TPM)
INPP5K — as a Regulated Gene

TFs regulating INPP5K 0 TFs

Transcription factors with Perturb-seq knockdown data for INPP5K. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INPP5K upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to INPP5K

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INPP5K, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:1,268,002–1,268,635 248.4 kb Distal (>10kb) Multiome 644
chr17:1,399,339–1,400,718 116.5 kb Distal (>10kb) Multiome 879
chr17:1,455,335–1,456,916 60.4 kb Distal (>10kb) Multiome 879
chr17:1,484,963–1,486,119 31.4 kb Distal (>10kb) Multiome 562
chr17:1,487,906–1,488,733 28.5 kb Distal (>10kb) Multiome 597
chr17:1,490,717–1,492,156 25.3 kb Distal (>10kb) Multiome 675
chr17:1,515,722–1,517,330 41 bp At TSS Multiome 796
chr17:1,562,314–1,563,047 46.1 kb Distal (>10kb) Multiome 685
chr17:1,589,843–1,590,457 73.4 kb Distal (>10kb) Multiome 538
chr17:1,627,811–1,629,617 112.0 kb Distal (>10kb) Multiome 753
chr17:1,642,697–1,644,482 126.6 kb Distal (>10kb) Multiome 467
chr17:1,648,163–1,650,244 132.4 kb Distal (>10kb) Multiome 932
chr17:1,684,343–1,685,342 168.2 kb Distal (>10kb) Multiome 728
chr17:1,710,017–1,710,765 193.7 kb Distal (>10kb) Multiome 500
chr17:1,713,886–1,717,908 200.8 kb Distal (>10kb) Multiome 1042
chr17:1,724,373–1,725,206 208.0 kb Distal (>10kb) Multiome 720

Genome Browser

Genomic view of the INPP5K locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:1,258,002 – 1,735,206
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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