The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for INPP5F. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INPP5F upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INPP5F, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:119,542,175–119,543,695 | 275.8 kb | Distal (>10kb) Multiome | 709 | |
| chr10:119,596,043–119,597,595 | 221.6 kb | Distal (>10kb) Multiome | 893 | |
| chr10:119,650,691–119,652,293 | 167.4 kb | Distal (>10kb) Multiome | 828 | |
| chr10:119,660,009–119,660,666 | 158.3 kb | Distal (>10kb) Multiome | 146 | |
| chr10:119,686,526–119,688,685 | 130.4 kb | Distal (>10kb) Multiome | 790 | |
| chr10:119,725,081–119,726,842 | 92.7 kb | Distal (>10kb) Multiome | 818 | |
| chr10:119,817,887–119,819,190 | 155 bp | At TSS Multiome | 334 | |
| chr10:119,872,104–119,873,627 | 54.3 kb | Distal (>10kb) Multiome | 835 | |
| chr10:119,892,259–119,893,097 | 73.9 kb | Distal (>10kb) Multiome | 957 |
Genomic view of the INPP5F locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.