Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Located in cytosol; fibrillar center; and nucleoplasm. Part of Ino80 complex and MLL1 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for INO80C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INO80C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INO80C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:35,240,066–35,241,553 | 256.9 kb | Distal (>10kb) Multiome | 906 | |
| chr18:35,289,760–35,290,683 | 207.7 kb | Distal (>10kb) Multiome | 970 | |
| chr18:35,343,705–35,344,835 | 153.6 kb | Distal (>10kb) Multiome | 916 | |
| chr18:35,376,423–35,377,702 | 120.7 kb | Distal (>10kb) Multiome | 673 | |
| chr18:35,488,095–35,488,748 | 9.3 kb | Proximal (<10kb) Multiome | 82 | |
| chr18:35,489,484–35,489,912 | 8.0 kb | Proximal (<10kb) | 18 | |
| chr18:35,491,193–35,492,049 | 5.9 kb | Proximal (<10kb) | 100 | |
| chr18:35,496,979–35,498,336 | 137 bp | At TSS Multiome | 1055 | |
| chr18:35,580,775–35,581,562 | 83.6 kb | Distal (>10kb) Multiome | 563 |
Genomic view of the INO80C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.