This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ING1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ING1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ING1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:110,485,584–110,487,244 | 227.1 kb | Distal (>10kb) Multiome | 272 | |
| chr13:110,540,846–110,542,010 | 172.3 kb | Distal (>10kb) Multiome | 268 | |
| chr13:110,561,007–110,562,237 | 151.9 kb | Distal (>10kb) Multiome | 710 | |
| chr13:110,615,145–110,616,475 | 98.1 kb | Distal (>10kb) Multiome | 792 | |
| chr13:110,644,706–110,645,508 | 68.6 kb | Distal (>10kb) Multiome | 290 | |
| chr13:110,705,702–110,706,922 | 7.4 kb | Proximal (<10kb) Multiome | 770 | |
| chr13:110,712,027–110,716,477 | 1.9 kb | Proximal (<10kb) Multiome | 1162 | |
| chr13:110,717,252–110,717,814 | 3.6 kb | Proximal (<10kb) | 68 | |
| chr13:110,812,187–110,813,068 | 99.0 kb | Distal (>10kb) Multiome HiCAR | 129 | |
| chr13:110,914,077–110,916,083 | 201.7 kb | Distal (>10kb) Multiome | 897 |
Genomic view of the ING1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.