This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
Transcription factors with Perturb-seq knockdown data for IMPA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IMPA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IMPA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:81,630,496–81,631,299 | 55.3 kb | Distal (>10kb) Multiome | 326 | |
| chr8:81,685,772–81,686,622 | 26 bp | At TSS Multiome | 915 | |
| chr8:81,720,515–81,721,822 | 35.0 kb | Distal (>10kb) Multiome | 750 | |
| chr8:81,731,713–81,733,032 | 46.4 kb | Distal (>10kb) Multiome | 732 | |
| chr8:81,895,652–81,897,396 | 209.9 kb | Distal (>10kb) Multiome | 316 | |
| chr8:81,897,889–81,899,280 | 211.9 kb | Distal (>10kb) Multiome | 138 | |
| chr8:81,903,428–81,904,466 | 217.5 kb | Distal (>10kb) Multiome | 155 | |
| chr8:81,912,367–81,913,089 | 226.4 kb | Distal (>10kb) Multiome | 113 |
Genomic view of the IMPA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.