The protein encoded by this gene shares similarity with several thiamine pyrophosphate-binding proteins identified in bacteria, yeast, and plants. The highest degree of similarity is found with bacterial acetolactate synthases (AHAS), which are enzymes that catalyze the first step in branched-chain amino acid biosynthesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ILVBL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ILVBL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ILVBL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:14,979,199–14,980,219 | 146.0 kb | Distal (>10kb) Multiome | 147 | |
| chr19:15,010,607–15,011,356 | 114.8 kb | Distal (>10kb) Multiome | 122 | |
| chr19:15,073,077–15,073,718 | 52.4 kb | Distal (>10kb) Multiome | 204 | |
| chr19:15,106,942–15,107,576 | 18.5 kb | Distal (>10kb) Multiome | 339 | |
| chr19:15,113,323–15,113,828 | 12.2 kb | Distal (>10kb) Multiome | 116 | |
| chr19:15,124,546–15,126,107 | 78 bp | At TSS Multiome | 949 | |
| chr19:15,177,520–15,178,026 | 51.9 kb | Distal (>10kb) Multiome | 499 | |
| chr19:15,180,886–15,181,623 | 55.5 kb | Distal (>10kb) Multiome | 355 | |
| chr19:15,195,187–15,196,375 | 70.3 kb | Distal (>10kb) Multiome | 408 | |
| chr19:15,199,629–15,201,437 | 74.3 kb | Distal (>10kb) Multiome | 398 | |
| chr19:15,222,727–15,224,168 | 97.7 kb | Distal (>10kb) Multiome | 521 | |
| chr19:15,231,632–15,233,858 | 107.4 kb | Distal (>10kb) Multiome | 414 | |
| chr19:15,324,741–15,325,392 | 199.2 kb | Distal (>10kb) Multiome | 183 | |
| chr19:15,331,471–15,332,992 | 206.8 kb | Distal (>10kb) Multiome | 641 | |
| chr19:15,378,833–15,380,802 | 254.1 kb | Distal (>10kb) Multiome | 913 | |
| chr19:15,418,493–15,419,441 | 293.4 kb | Distal (>10kb) Multiome | 892 | |
| chr19:15,432,448–15,433,787 | 307.1 kb | Distal (>10kb) Multiome HiCAR | 766 | |
| chr19:16,184,971–16,186,029 | 1059.6 kb | Distal (>10kb) Multiome HiCAR | 658 | |
| chr19:16,197,472–16,198,501 | 1072.1 kb | Distal (>10kb) Multiome HiCAR | 806 |
Genomic view of the ILVBL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.