This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for IL17RE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IL17RE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IL17RE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:9,649,068–9,649,746 | 253.5 kb | Distal (>10kb) Multiome | 793 | |
| chr3:9,703,572–9,705,701 | 197.7 kb | Distal (>10kb) Multiome | 664 | |
| chr3:9,727,013–9,727,518 | 175.6 kb | Distal (>10kb) Multiome | 264 | |
| chr3:9,730,724–9,732,470 | 171.5 kb | Distal (>10kb) Multiome | 934 | |
| chr3:9,749,252–9,750,525 | 152.9 kb | Distal (>10kb) Multiome | 873 | |
| chr3:9,769,503–9,770,124 | 132.9 kb | Distal (>10kb) Multiome | 504 | |
| chr3:9,792,176–9,793,536 | 110.0 kb | Distal (>10kb) Multiome | 915 | |
| chr3:9,809,609–9,810,744 | 92.7 kb | Distal (>10kb) Multiome | 437 | |
| chr3:9,843,116–9,844,397 | 58.9 kb | Distal (>10kb) Multiome HiCAR | 787 | |
| chr3:9,862,465–9,863,231 | 40.0 kb | Distal (>10kb) Multiome | 581 | |
| chr3:9,890,247–9,891,058 | 12.2 kb | Distal (>10kb) Multiome | 969 | |
| chr3:9,902,504–9,903,128 | 49 bp | At TSS Multiome | 396 | |
| chr3:9,914,983–9,916,160 | 12.4 kb | Distal (>10kb) Multiome | 668 | |
| chr3:9,916,644–9,917,412 | 14.2 kb | Distal (>10kb) Multiome | 519 | |
| chr3:9,932,470–9,934,327 | 30.9 kb | Distal (>10kb) Multiome | 1035 | |
| chr3:9,946,152–9,947,739 | 44.6 kb | Distal (>10kb) Multiome | 898 | |
| chr3:9,951,898–9,952,503 | 49.4 kb | Distal (>10kb) Multiome | 484 | |
| chr3:9,986,547–9,987,409 | 84.1 kb | Distal (>10kb) Multiome | 907 | |
| chr3:10,008,678–10,009,458 | 106.3 kb | Distal (>10kb) Multiome | 240 | |
| chr3:10,010,580–10,011,700 | 108.4 kb | Distal (>10kb) Multiome | 540 | |
| chr3:10,025,904–10,026,762 | 123.6 kb | Distal (>10kb) Multiome | 871 | |
| chr3:10,115,394–10,116,145 | 212.8 kb | Distal (>10kb) Multiome | 809 | |
| chr3:10,141,441–10,142,425 | 239.0 kb | Distal (>10kb) Multiome | 894 | |
| chr3:10,164,557–10,165,625 | 262.1 kb | Distal (>10kb) Multiome | 718 |
Genomic view of the IL17RE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.