This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for IL17RC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IL17RC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IL17RC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:9,649,068–9,649,746 | 267.8 kb | Distal (>10kb) Multiome | 793 | |
| chr3:9,703,572–9,705,701 | 212.0 kb | Distal (>10kb) Multiome | 664 | |
| chr3:9,727,013–9,727,518 | 189.9 kb | Distal (>10kb) Multiome | 264 | |
| chr3:9,730,724–9,732,470 | 185.8 kb | Distal (>10kb) Multiome | 934 | |
| chr3:9,749,252–9,750,525 | 167.2 kb | Distal (>10kb) Multiome | 873 | |
| chr3:9,769,503–9,770,124 | 147.2 kb | Distal (>10kb) Multiome | 504 | |
| chr3:9,792,176–9,793,536 | 124.3 kb | Distal (>10kb) Multiome | 915 | |
| chr3:9,809,609–9,810,744 | 107.0 kb | Distal (>10kb) Multiome | 437 | |
| chr3:9,843,116–9,844,397 | 73.1 kb | Distal (>10kb) Multiome | 787 | |
| chr3:9,862,465–9,863,231 | 54.3 kb | Distal (>10kb) Multiome | 581 | |
| chr3:9,890,247–9,891,058 | 26.5 kb | Distal (>10kb) Multiome | 969 | |
| chr3:9,902,504–9,903,128 | 14.3 kb | Distal (>10kb) Multiome | 396 | |
| chr3:9,914,983–9,916,160 | 1.9 kb | Proximal (<10kb) Multiome | 668 | |
| chr3:9,916,644–9,917,412 | 40 bp | At TSS Multiome | 519 | |
| chr3:9,932,470–9,934,327 | 15.7 kb | Distal (>10kb) Multiome | 1035 | |
| chr3:9,946,152–9,947,739 | 29.5 kb | Distal (>10kb) Multiome | 898 | |
| chr3:9,951,898–9,952,503 | 35.2 kb | Distal (>10kb) Multiome | 484 | |
| chr3:9,986,547–9,987,409 | 69.8 kb | Distal (>10kb) Multiome | 907 | |
| chr3:10,008,678–10,009,458 | 92.0 kb | Distal (>10kb) Multiome | 240 | |
| chr3:10,010,580–10,011,700 | 94.1 kb | Distal (>10kb) Multiome | 540 | |
| chr3:10,025,904–10,026,762 | 109.2 kb | Distal (>10kb) Multiome | 871 | |
| chr3:10,115,394–10,116,145 | 198.5 kb | Distal (>10kb) Multiome | 809 | |
| chr3:10,141,441–10,142,425 | 224.7 kb | Distal (>10kb) Multiome | 894 | |
| chr3:10,164,557–10,165,625 | 247.8 kb | Distal (>10kb) Multiome | 718 |
Genomic view of the IL17RC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.