IKBKG
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma | FIP-3, FIP3, Fip3p, IKK-gamma, IKKAP1, IKKG, NEMO, IP1, IP2

This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]

Biological processes 59 terms
DNA damage response (GO:0006974)DNA damage response (GO:0006974)IkappaB kinase complex (GO:0008385)IkappaB kinase complex (GO:0008385)IkappaB kinase complex (GO:0008385)IkappaB kinase complex (GO:0008385)K63-linked polyubiquitin modification-dependent protein binding (GO:0070530)K63-linked polyubiquitin modification-dependent protein binding (GO:0070530)K63-linked polyubiquitin modification-dependent protein binding (GO:0070530)T cell receptor signaling pathway (GO:0050852)anoikis (GO:0043276)anoikis (GO:0043276)apoptotic process (GO:0006915)canonical NF-kappaB signal transduction (GO:0007249)canonical NF-kappaB signal transduction (GO:0007249)canonical NF-kappaB signal transduction (GO:0007249)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)defense response to bacterium (GO:0042742)establishment of vesicle localization (GO:0051650)identical protein binding (GO:0042802)identical protein binding (GO:0042802)immune response (GO:0006955)inflammatory response (GO:0006954)innate immune response (GO:0045087)linear polyubiquitin binding (GO:1990450)mitotic spindle (GO:0072686)negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902236)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)polyubiquitin modification-dependent protein binding (GO:0031593)positive regulation of T cell receptor signaling pathway (GO:0050862)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of gene expression (GO:0010628)positive regulation of macroautophagy (GO:0016239)positive regulation of macroautophagy (GO:0016239)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of ubiquitin-dependent protein catabolic process (GO:2000060)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)protein-containing complex (GO:0032991)protein-containing complex assembly (GO:0065003)response to virus (GO:0009615)signaling adaptor activity (GO:0035591)signaling adaptor activity (GO:0035591)spindle pole (GO:0000922)transferrin receptor binding (GO:1990459)ubiquitin ligase complex (GO:0000151)ubiquitin protein ligase binding (GO:0031625)
Expression (TPM)
IKBKG — as a Regulated Gene

TFs regulating IKBKG 0 TFs

Transcription factors with Perturb-seq knockdown data for IKBKG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IKBKG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to IKBKG

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IKBKG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chrX:154,368,993–154,370,053 177.8 kb Distal (>10kb) Multiome 546
chrX:154,370,757–154,372,188 176.0 kb Distal (>10kb) Multiome 764
chrX:154,378,063–154,379,701 168.4 kb Distal (>10kb) Multiome 687
chrX:154,397,430–154,398,941 149.2 kb Distal (>10kb) Multiome 871
chrX:154,409,052–154,409,671 138.0 kb Distal (>10kb) Multiome 396
chrX:154,428,419–154,428,969 118.7 kb Distal (>10kb) Multiome 601
chrX:154,436,501–154,437,435 110.5 kb Distal (>10kb) Multiome 448
chrX:154,457,605–154,458,763 89.3 kb Distal (>10kb) Multiome 467
chrX:154,478,385–154,479,590 68.3 kb Distal (>10kb) Multiome 707
chrX:154,490,259–154,491,245 56.6 kb Distal (>10kb) Multiome 567
chrX:154,515,811–154,517,059 31.0 kb Distal (>10kb) Multiome 590
chrX:154,546,514–154,547,906 179 bp At TSS Multiome 691
chrX:154,762,385–154,763,339 215.4 kb Distal (>10kb) Multiome 675
chrX:154,805,199–154,805,850 258.1 kb Distal (>10kb) Multiome 481

Genome Browser

Genomic view of the IKBKG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chrX:154,358,993 – 154,815,850
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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