The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:140,363,055–140,363,697 | 284.4 kb | Distal (>10kb) Multiome HiCAR | 542 | |
| chr5:140,372,779–140,373,538 | 274.7 kb | Distal (>10kb) Multiome | 302 | |
| chr5:140,400,395–140,402,925 | 246.3 kb | Distal (>10kb) Multiome | 1129 | |
| chr5:140,546,917–140,548,500 | 100.2 kb | Distal (>10kb) Multiome HiCAR | 784 | |
| chr5:140,556,971–140,557,959 | 90.3 kb | Distal (>10kb) Multiome HiCAR | 886 | |
| chr5:140,564,055–140,565,123 | 83.2 kb | Distal (>10kb) Multiome HiCAR | 827 | |
| chr5:140,639,043–140,640,146 | 8.4 kb | Proximal (<10kb) Multiome | 898 | |
| chr5:140,647,175–140,648,159 | 113 bp | At TSS Multiome | 863 | |
| chr5:140,664,368–140,665,161 | 16.9 kb | Distal (>10kb) Multiome | 856 | |
| chr5:140,673,200–140,673,759 | 25.8 kb | Distal (>10kb) Multiome | 144 | |
| chr5:140,691,053–140,691,933 | 43.7 kb | Distal (>10kb) Multiome | 924 | |
| chr5:140,699,981–140,700,742 | 52.5 kb | Distal (>10kb) Multiome | 607 | |
| chr5:140,710,433–140,711,671 | 63.2 kb | Distal (>10kb) Multiome | 856 | |
| chr5:140,718,340–140,718,978 | 70.8 kb | Distal (>10kb) Multiome | 763 | |
| chr5:140,725,570–140,726,438 | 78.2 kb | Distal (>10kb) Multiome | 719 | |
| chr5:140,925,961–140,927,592 | 278.7 kb | Distal (>10kb) Multiome | 419 |
Genomic view of the IK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.