The protein encoded by this gene is part of the intraflagellar transport complex B and is necessary for the function of motile and sensory cilia. Defects in this gene are a cause of asphyxiating thoracic dystrophy 2 (ATD2). Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for IFT80. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFT80 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFT80, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:160,224,325–160,227,043 | 174.0 kb | Distal (>10kb) Multiome | 759 | |
| chr3:160,395,273–160,396,017 | 3.2 kb | Proximal (<10kb) | 186 | |
| chr3:160,398,871–160,400,586 | 179 bp | At TSS Multiome | 790 | |
| chr3:160,400,667–160,401,119 | 1.4 kb | Proximal (<10kb) | 316 | |
| chr3:160,448,903–160,450,623 | 50.4 kb | Distal (>10kb) Multiome | 864 | |
| chr3:160,564,297–160,566,417 | 166.1 kb | Distal (>10kb) Multiome | 933 | |
| chr3:160,676,210–160,677,318 | 277.2 kb | Distal (>10kb) Multiome | 203 |
Genomic view of the IFT80 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.