This gene encodes a GTP-binding protein that is a core component of the intraflagellar transport complex B. Characterization of the similar Chlamydomonas protein indicates a function in cell cycle control. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for IFT27. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFT27 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFT27, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:36,481,299–36,482,295 | 294.2 kb | Distal (>10kb) Multiome | 842 | |
| chr22:36,506,747–36,507,706 | 269.0 kb | Distal (>10kb) Multiome | 964 | |
| chr22:36,528,683–36,529,724 | 246.8 kb | Distal (>10kb) Multiome HiCAR | 1012 | |
| chr22:36,775,650–36,776,664 | 214 bp | At TSS Multiome | 472 | |
| chr22:36,782,072–36,782,305 | 6.0 kb | Proximal (<10kb) | 296 | |
| chr22:36,856,048–36,856,669 | 80.3 kb | Distal (>10kb) Multiome | 475 | |
| chr22:37,018,841–37,020,143 | 243.5 kb | Distal (>10kb) Multiome | 684 | |
| chr22:37,051,550–37,052,220 | 275.7 kb | Distal (>10kb) Multiome | 351 |
Genomic view of the IFT27 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.