This locus represents naturally occurring readthrough transcription between the neighboring IFNAR2 (interferon alpha and beta receptor subunit 2) and IL10RB (interleukin 10 receptor subunit beta) genes on chromosome 21. The readthrough transcript encodes a protein that shares sequence identity with the upstream and downstream gene products. [provided by RefSeq, Nov 2022]
Transcription factors with Perturb-seq knockdown data for IFNAR2-IL10RB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFNAR2-IL10RB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFNAR2-IL10RB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:33,227,058–33,227,261 | 2.7 kb | Proximal (<10kb) | 17 | |
| chr21:33,229,605–33,230,926 | at TSS | At TSS | 722 | |
| chr21:33,235,040–33,235,405 | 5.1 kb | Proximal (<10kb) | 106 |
Genomic view of the IFNAR2-IL10RB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.