IFI27

interferon alpha inducible protein 27 | FAM14D, ISG12, P27

Enables several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; identical protein binding activity; and lamin binding activity. Involved in several processes, including defense response to other organism; protein K48-linked ubiquitination; and pyroptotic inflammatory response. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of protein export from nucleus. Located in mitochondrial membrane and nuclear inner membrane. Is active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

Biological processes 30 terms

RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)apoptotic process (GO:0006915)apoptotic process (GO:0006915)defense response to virus (GO:0051607)endoplasmic reticulum membrane (GO:0005789)extrinsic apoptotic signaling pathway (GO:0097191)host-mediated perturbation of viral genome replication (GO:0044827)identical protein binding (GO:0042802)innate immune response (GO:0045087)intrinsic apoptotic signaling pathway (GO:0097193)lamin binding (GO:0005521)membrane (GO:0016020)mitochondrial membrane (GO:0031966)mitochondrial membrane (GO:0031966)mitochondrial membrane (GO:0031966)mitochondrial outer membrane (GO:0005741)mitochondrion (GO:0005739)mitochondrion (GO:0005739)molecular adaptor activity (GO:0060090)molecular adaptor activity (GO:0060090)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear envelope (GO:0005635)nuclear inner membrane (GO:0005637)nuclear inner membrane (GO:0005637)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein K48-linked ubiquitination (GO:0070936)protein binding (GO:0005515)pyroptotic inflammatory response (GO:0070269)regulation of protein export from nucleus (GO:0046825)type I interferon-mediated signaling pathway (GO:0060337)

Expression (TPM)