This gene encodes a small protein that is localized to the endoplasmic reticulum (ER) and may play a role in the ER stress response by mediating cell differentiation and apoptosis. Transcription of this gene is regulated by tumor necrosis factor alpha and specificity protein 1 (Sp1). Mutations in this gene may play a role in microcephaly, epilepsy, and diabetes syndrome (MEDS), and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for IER3IP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IER3IP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IER3IP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:46,916,768–46,918,244 | 258.9 kb | Distal (>10kb) Multiome | 715 | |
| chr18:46,946,455–46,947,310 | 229.5 kb | Distal (>10kb) Multiome | 249 | |
| chr18:47,149,543–47,151,037 | 26.0 kb | Distal (>10kb) Multiome | 824 | |
| chr18:47,175,919–47,176,532 | 62 bp | At TSS Multiome | 731 | |
| chr18:47,246,981–47,248,546 | 71.2 kb | Distal (>10kb) Multiome | 158 | |
| chr18:47,254,445–47,254,917 | 78.3 kb | Distal (>10kb) Multiome | 213 | |
| chr18:47,260,995–47,261,741 | 85.1 kb | Distal (>10kb) Multiome | 93 | |
| chr18:47,263,134–47,264,324 | 87.2 kb | Distal (>10kb) Multiome | 151 |
Genomic view of the IER3IP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.