This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for IDS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IDS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IDS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:147,911,262–147,912,822 | 1593.4 kb | Distal (>10kb) Multiome HiCAR | 688 | |
| chrX:149,504,289–149,504,497 | 808 bp | At TSS | 149 | |
| chrX:149,504,975–149,505,689 | 43 bp | At TSS Multiome | 530 | |
| chrX:149,512,335–149,512,782 | 7.0 kb | Proximal (<10kb) | 202 | |
| chrX:149,539,047–149,541,999 | 34.3 kb | Distal (>10kb) Multiome | 720 | |
| chrX:149,719,990–149,720,515 | 214.9 kb | Distal (>10kb) Multiome | 190 |
Genomic view of the IDS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.