This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ICAM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ICAM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ICAM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:10,027,570–10,028,022 | 243.3 kb | Distal (>10kb) Multiome | 753 | |
| chr19:10,086,000–10,086,942 | 184.8 kb | Distal (>10kb) Multiome | 614 | |
| chr19:10,095,848–10,096,951 | 174.9 kb | Distal (>10kb) Multiome | 572 | |
| chr19:10,106,123–10,106,748 | 164.8 kb | Distal (>10kb) Multiome | 842 | |
| chr19:10,119,464–10,120,287 | 151.2 kb | Distal (>10kb) Multiome | 818 | |
| chr19:10,194,229–10,195,372 | 76.2 kb | Distal (>10kb) Multiome | 939 | |
| chr19:10,230,671–10,231,665 | 39.7 kb | Distal (>10kb) Multiome | 595 | |
| chr19:10,251,723–10,252,663 | 19.1 kb | Distal (>10kb) Multiome | 969 | |
| chr19:10,269,513–10,270,051 | 1.5 kb | Proximal (<10kb) Multiome | 523 | |
| chr19:10,270,913–10,271,370 | 32 bp | At TSS Multiome | 753 | |
| chr19:10,288,709–10,290,833 | 17.7 kb | Distal (>10kb) Multiome | 688 | |
| chr19:10,292,085–10,293,198 | 21.4 kb | Distal (>10kb) Multiome | 441 | |
| chr19:10,315,359–10,316,478 | 44.8 kb | Distal (>10kb) Multiome | 830 | |
| chr19:10,332,816–10,334,107 | 62.4 kb | Distal (>10kb) Multiome | 882 | |
| chr19:10,334,573–10,335,642 | 63.9 kb | Distal (>10kb) Multiome | 584 | |
| chr19:10,352,359–10,354,435 | 81.6 kb | Distal (>10kb) Multiome | 447 | |
| chr19:10,380,209–10,381,218 | 109.6 kb | Distal (>10kb) Multiome HiCAR | 874 | |
| chr19:10,403,282–10,404,914 | 132.6 kb | Distal (>10kb) Multiome | 794 | |
| chr19:10,416,245–10,417,312 | 145.6 kb | Distal (>10kb) Multiome | 988 | |
| chr19:10,417,499–10,421,409 | 149.2 kb | Distal (>10kb) Multiome | 801 | |
| chr19:10,424,198–10,424,839 | 153.4 kb | Distal (>10kb) Multiome | 563 | |
| chr19:10,460,915–10,461,960 | 190.2 kb | Distal (>10kb) Multiome | 340 | |
| chr19:10,502,251–10,503,615 | 231.7 kb | Distal (>10kb) Multiome | 1013 | |
| chr19:10,514,009–10,514,960 | 243.3 kb | Distal (>10kb) Multiome | 172 | |
| chr19:10,517,347–10,518,104 | 246.6 kb | Distal (>10kb) Multiome | 338 | |
| chr19:10,543,499–10,544,302 | 272.7 kb | Distal (>10kb) Multiome | 617 | |
| chr19:10,565,054–10,566,439 | 294.9 kb | Distal (>10kb) Multiome | 923 | |
| chr19:10,568,225–10,569,839 | 297.9 kb | Distal (>10kb) Multiome | 871 |
Genomic view of the ICAM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.