Transcription factors with Perturb-seq knockdown data for HSPD1P6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSPD1P6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSPD1P6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:36,763,195–36,763,438 | 5.4 kb | Proximal (<10kb) | 39 | |
| chr3:36,763,790–36,765,063 | 3.7 kb | Proximal (<10kb) | 293 | |
| chr3:36,768,348–36,768,534 | 264 bp | At TSS | 3 | |
| chr3:36,769,689–36,770,426 | 890 bp | At TSS | 99 |
Genomic view of the HSPD1P6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.