HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HSF2BP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSF2BP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSF2BP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:42,234,400–42,235,305 | 1424.6 kb | Distal (>10kb) Multiome HiCAR | 427 | |
| chr21:42,892,360–42,893,974 | 766.3 kb | Distal (>10kb) Multiome HiCAR | 992 | |
| chr21:43,659,125–43,659,916 | 112 bp | At TSS Multiome | 989 | |
| chr21:43,718,478–43,719,766 | 59.7 kb | Distal (>10kb) Multiome | 782 | |
| chr21:43,728,503–43,729,213 | 69.4 kb | Distal (>10kb) Multiome | 905 | |
| chr21:43,740,577–43,741,104 | 81.4 kb | Distal (>10kb) Multiome | 198 | |
| chr21:43,775,786–43,776,893 | 117.0 kb | Distal (>10kb) Multiome | 782 | |
| chr21:43,788,879–43,790,067 | 130.0 kb | Distal (>10kb) Multiome | 930 | |
| chr21:43,864,215–43,864,709 | 204.9 kb | Distal (>10kb) Multiome | 538 | |
| chr21:43,865,135–43,865,798 | 206.0 kb | Distal (>10kb) Multiome | 333 | |
| chr21:43,883,997–43,884,476 | 224.8 kb | Distal (>10kb) Multiome | 418 | |
| chr21:43,921,393–43,922,764 | 262.5 kb | Distal (>10kb) Multiome | 622 |
Genomic view of the HSF2BP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.