Located in intermediate filament cytoskeleton and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HSDL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSDL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSDL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:83,888,352–83,889,387 | 256.4 kb | Distal (>10kb) Multiome | 237 | |
| chr16:83,898,559–83,899,828 | 246.1 kb | Distal (>10kb) Multiome | 773 | |
| chr16:83,926,399–83,927,376 | 218.3 kb | Distal (>10kb) Multiome | 532 | |
| chr16:83,968,110–83,968,725 | 176.7 kb | Distal (>10kb) Multiome | 261 | |
| chr16:84,013,600–84,015,009 | 130.9 kb | Distal (>10kb) Multiome | 388 | |
| chr16:84,043,411–84,043,885 | 101.4 kb | Distal (>10kb) Multiome | 292 | |
| chr16:84,062,518–84,063,095 | 82.3 kb | Distal (>10kb) Multiome | 330 | |
| chr16:84,116,331–84,117,716 | 28.3 kb | Distal (>10kb) Multiome | 1013 | |
| chr16:84,144,637–84,145,742 | 50 bp | At TSS Multiome | 679 | |
| chr16:84,186,615–84,187,246 | 41.9 kb | Distal (>10kb) Multiome | 848 | |
| chr16:84,268,108–84,268,844 | 123.3 kb | Distal (>10kb) Multiome | 42 | |
| chr16:84,367,919–84,368,944 | 223.3 kb | Distal (>10kb) Multiome | 287 |
Genomic view of the HSDL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.