HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010]
Transcription factors with Perturb-seq knockdown data for HSD17B7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSD17B7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSD17B7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:162,069,229–162,071,225 | 720.9 kb | Distal (>10kb) Multiome HiCAR | 662 | |
| chr1:162,497,482–162,498,431 | 292.8 kb | Distal (>10kb) Multiome | 778 | |
| chr1:162,560,729–162,562,552 | 229.2 kb | Distal (>10kb) Multiome | 1005 | |
| chr1:162,696,268–162,696,983 | 94.1 kb | Distal (>10kb) Multiome | 473 | |
| chr1:162,790,314–162,790,698 | 3 bp | At TSS | 217 | |
| chr1:162,822,352–162,823,207 | 32.1 kb | Distal (>10kb) Multiome | 350 | |
| chr1:163,069,170–163,069,674 | 278.6 kb | Distal (>10kb) Multiome | 172 |
Genomic view of the HSD17B7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.