The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for HSD17B6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSD17B6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSD17B6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:56,468,239–56,468,840 | 283.6 kb | Distal (>10kb) Multiome | 907 | |
| chr12:56,487,633–56,488,590 | 263.9 kb | Distal (>10kb) Multiome | 784 | |
| chr12:56,629,725–56,630,674 | 121.9 kb | Distal (>10kb) Multiome | 759 | |
| chr12:56,633,838–56,637,505 | 117.8 kb | Distal (>10kb) Multiome | 1037 | |
| chr12:56,645,530–56,646,466 | 106.0 kb | Distal (>10kb) Multiome | 902 | |
| chr12:56,687,276–56,689,898 | 63.8 kb | Distal (>10kb) Multiome | 1162 | |
| chr12:56,724,695–56,725,713 | 26.8 kb | Distal (>10kb) Multiome | 972 | |
| chr12:56,751,814–56,752,566 | 87 bp | At TSS Multiome | 765 | |
| chr12:57,006,056–57,006,942 | 254.4 kb | Distal (>10kb) Multiome | 422 | |
| chr12:57,110,045–57,111,598 | 358.2 kb | Distal (>10kb) Multiome HiCAR | 656 | |
| chr12:57,111,611–57,112,633 | 359.7 kb | Distal (>10kb) Multiome HiCAR | 940 |
Genomic view of the HSD17B6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.