Transcription factors with Perturb-seq knockdown data for HSD17B2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSD17B2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSD17B2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:81,778,844–81,779,928 | 284.0 kb | Distal (>10kb) Multiome | 538 | |
| chr16:81,784,102–81,784,987 | 278.6 kb | Distal (>10kb) Multiome | 131 | |
| chr16:82,169,820–82,170,830 | 107.0 kb | Distal (>10kb) Multiome | 1026 | |
| chr16:82,229,526–82,230,317 | 166.8 kb | Distal (>10kb) Multiome | 255 |
Genomic view of the HSD17B2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.