This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]
Transcription factors with Perturb-seq knockdown data for HSD17B10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSD17B10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSD17B10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:53,224,805–53,225,756 | 209.0 kb | Distal (>10kb) Multiome | 825 | |
| chrX:53,421,898–53,423,292 | 11.6 kb | Distal (>10kb) Multiome | 745 | |
| chrX:53,434,290–53,434,606 | at TSS | At TSS | 423 | |
| chrX:53,441,598–53,442,101 | 7.5 kb | Proximal (<10kb) Multiome | 254 | |
| chrX:53,683,043–53,684,640 | 249.9 kb | Distal (>10kb) Multiome | 710 | |
| chrX:53,686,122–53,687,094 | 252.3 kb | Distal (>10kb) Multiome | 540 |
Genomic view of the HSD17B10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.