This gene is a member of the hydroxysteroid dehydrogenase family. The encoded protein is similar to an enzyme that catalyzes the interconversion of inactive to active glucocorticoids (e.g. cortisone). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for HSD11B1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSD11B1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSD11B1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:5,397,820–5,398,866 | 282.2 kb | Distal (>10kb) Multiome | 137 | |
| chr19:5,436,304–5,437,277 | 243.8 kb | Distal (>10kb) Multiome | 227 | |
| chr19:5,536,326–5,536,869 | 143.9 kb | Distal (>10kb) Multiome | 306 | |
| chr19:5,621,964–5,623,739 | 57.7 kb | Distal (>10kb) Multiome | 857 | |
| chr19:5,679,757–5,681,464 | 204 bp | At TSS Multiome | 884 | |
| chr19:5,686,329–5,687,994 | 6.4 kb | Proximal (<10kb) Multiome | 693 | |
| chr19:5,689,735–5,690,874 | 9.7 kb | Proximal (<10kb) Multiome | 960 | |
| chr19:5,719,717–5,721,174 | 39.8 kb | Distal (>10kb) Multiome | 985 | |
| chr19:5,790,527–5,791,509 | 110.3 kb | Distal (>10kb) Multiome | 965 | |
| chr19:5,803,750–5,806,128 | 124.6 kb | Distal (>10kb) Multiome | 858 | |
| chr19:5,826,528–5,829,726 | 147.5 kb | Distal (>10kb) Multiome | 1037 | |
| chr19:5,903,474–5,905,358 | 224.0 kb | Distal (>10kb) Multiome | 1027 | |
| chr19:5,977,406–5,978,787 | 297.6 kb | Distal (>10kb) Multiome | 1028 |
Genomic view of the HSD11B1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.