The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1/Hs1-interacting protein that may be involved in lymphocyte activation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HS1BP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HS1BP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HS1BP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:20,350,092–20,352,594 | 300.2 kb | Distal (>10kb) Multiome | 1127 | |
| chr2:20,446,303–20,448,812 | 204.1 kb | Distal (>10kb) Multiome HiCAR | 1072 | |
| chr2:20,510,011–20,510,507 | 140.9 kb | Distal (>10kb) Multiome | 307 | |
| chr2:20,524,538–20,525,515 | 126.3 kb | Distal (>10kb) Multiome | 598 | |
| chr2:20,635,654–20,636,525 | 15.1 kb | Distal (>10kb) Multiome | 590 | |
| chr2:20,642,270–20,642,905 | 8.6 kb | Proximal (<10kb) Multiome | 430 | |
| chr2:20,650,354–20,651,898 | 24 bp | At TSS Multiome | 916 | |
| chr2:20,661,529–20,662,170 | 10.6 kb | Distal (>10kb) Multiome | 410 | |
| chr2:20,665,114–20,668,353 | 15.8 kb | Distal (>10kb) Multiome | 705 | |
| chr2:20,822,123–20,823,451 | 171.9 kb | Distal (>10kb) Multiome | 1058 | |
| chr2:20,915,185–20,916,351 | 264.6 kb | Distal (>10kb) Multiome | 119 |
Genomic view of the HS1BP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.