HPD

4-hydroxyphenylpyruvate dioxygenase | 4-HPPD, 4HPPD, GLOD3, HPPD, PPD

The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Biological processes 25 terms

4-hydroxyphenylpyruvate dioxygenase activity (GO:0003868)4-hydroxyphenylpyruvate dioxygenase activity (GO:0003868)4-hydroxyphenylpyruvate dioxygenase activity (GO:0003868)4-hydroxyphenylpyruvate dioxygenase activity (GO:0003868)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)L-phenylalanine catabolic process (GO:0006559)L-tyrosine catabolic process (GO:0006572)L-tyrosine catabolic process (GO:0006572)L-tyrosine catabolic process (GO:0006572)L-tyrosine catabolic process (GO:0006572)L-tyrosine catabolic process (GO:0006572)aromatic amino acid metabolic process (GO:0009072)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)extracellular exosome (GO:0070062)mRNA m(6)A methyltransferase activity (GO:0001734)nucleus (GO:0005634)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen (GO:0016701)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)

Expression (TPM)