The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for HPCAL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HPCAL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HPCAL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:10,042,279–10,044,590 | 258.8 kb | Distal (>10kb) Multiome | 999 | |
| chr2:10,057,234–10,058,147 | 245.2 kb | Distal (>10kb) Multiome | 504 | |
| chr2:10,079,477–10,080,916 | 222.8 kb | Distal (>10kb) Multiome | 381 | |
| chr2:10,097,234–10,097,850 | 205.3 kb | Distal (>10kb) Multiome | 372 | |
| chr2:10,120,050–10,120,940 | 182.5 kb | Distal (>10kb) Multiome | 1054 | |
| chr2:10,121,967–10,123,307 | 180.3 kb | Distal (>10kb) Multiome | 958 | |
| chr2:10,301,765–10,304,331 | 165 bp | At TSS Multiome | 899 | |
| chr2:10,409,111–10,409,643 | 106.4 kb | Distal (>10kb) Multiome HiCAR | 552 | |
| chr2:10,432,300–10,432,926 | 129.8 kb | Distal (>10kb) Multiome | 273 | |
| chr2:10,447,433–10,449,378 | 145.6 kb | Distal (>10kb) Multiome | 1156 |
Genomic view of the HPCAL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.