Transcription factors with Perturb-seq knockdown data for HNRNPD-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HNRNPD-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HNRNPD-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:82,284,318–82,285,814 | 89.0 kb | Distal (>10kb) Multiome | 566 | |
| chr4:82,372,612–82,374,867 | 128 bp | At TSS Multiome | 1174 | |
| chr4:82,428,720–82,431,310 | 56.4 kb | Distal (>10kb) Multiome | 1120 | |
| chr4:82,561,307–82,562,355 | 187.8 kb | Distal (>10kb) Multiome | 327 | |
| chr4:82,667,793–82,668,466 | 294.0 kb | Distal (>10kb) Multiome | 123 |
Genomic view of the HNRNPD-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.