The protein encoded by this gene is a member of the NKL homeobox family of transcription factors. Members in this family are of ancient origin and play an important role in organ development during embryogenesis. A related mouse protein plays a role in patterning of inner ear structures. In humans, variations in a region containing this gene have been associated with inner ear malformations, vestibular dysfunction, and hearing loss. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for HMX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HMX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HMX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:123,139,520–123,140,375 | 7.8 kb | Proximal (<10kb) | 456 | |
| chr10:123,144,827–123,145,179 | 3.0 kb | Proximal (<10kb) | 98 | |
| chr10:123,147,570–123,148,872 | at TSS | At TSS | 310 | |
| chr10:123,149,449–123,150,210 | 1.3 kb | Proximal (<10kb) | 125 | |
| chr10:123,150,788–123,151,726 | 2.7 kb | Proximal (<10kb) | 224 | |
| chr10:123,153,975–123,155,184 | 5.8 kb | Proximal (<10kb) | 787 |
Genomic view of the HMX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.