Predicted to enable axon guidance receptor activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and synapse organization. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for HMCN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HMCN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HMCN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:130,042,478–130,043,723 | 222.5 kb | Distal (>10kb) Multiome | 793 | |
| chr9:130,171,788–130,172,513 | 93.6 kb | Distal (>10kb) Multiome | 253 | |
| chr9:130,243,058–130,243,650 | 22.4 kb | Distal (>10kb) Multiome | 380 | |
| chr9:130,265,477–130,266,015 | 6 bp | At TSS Multiome | 214 | |
| chr9:130,433,040–130,433,900 | 167.7 kb | Distal (>10kb) Multiome | 543 | |
| chr9:130,444,394–130,446,012 | 179.0 kb | Distal (>10kb) Multiome | 568 | |
| chr9:130,446,125–130,446,731 | 180.7 kb | Distal (>10kb) Multiome | 326 |
Genomic view of the HMCN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.