This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HLTF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HLTF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HLTF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:148,991,054–148,992,463 | 95.0 kb | Distal (>10kb) Multiome | 826 | |
| chr3:149,085,604–149,087,032 | 36 bp | At TSS Multiome | 1012 | |
| chr3:149,129,236–149,130,370 | 43.2 kb | Distal (>10kb) Multiome | 951 | |
| chr3:149,196,583–149,197,308 | 110.4 kb | Distal (>10kb) Multiome | 127 | |
| chr3:149,198,425–149,199,153 | 112.3 kb | Distal (>10kb) Multiome | 164 | |
| chr3:149,352,512–149,352,988 | 266.2 kb | Distal (>10kb) Multiome | 387 |
Genomic view of the HLTF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.